Foreword
Expect to be gather/spend this much material at endgame. Ultimately, it is up to you which style you prefer — farming on the go, or pre-farming. The calculations below will show which way is best to utilize your resin and give you the most value + from my own experience.
*Calculated numbers are based on WL8, AR57, small goldfish 🐡 (no refill).
*Update (5/8/2022): As time has proven, Mondstadt & Liyue weapon materials are still relevant to present day, and very likely will continue to do so in the future, unless miHoYo replaces them all with Inazuma weapons once Sumeru banners start showing up.

Calculation
☑ 100 x Lv.20 Artifacts
Domain run:
5 days of resin: 800 resin = min. 504,000 fodder exp
(on the basis that each domain drop is 12,600 exp per 20 resin x 40 rounds)
Enough fodder to raise → 1x lv.20 5☆ artifact + 1x lv.18 5☆ artifact
(not counting any x2 or x5 bonus that might occur in between)
Daily free fodder:
85,000 exp x 5 days = 425,000 exp
Pretty decent for something that doesn't require resin usage, especially when comparing to exp earned through domain farming (just 79,000 exp difference — basically just 1 day shy of free fodder).
*droprate source: link



☑ 13 x 50 Boss Mats
This took me 1.5 months to complete. Research is done to get accurate number for droprate calculation.
Boss run:
160 daily resin x 5 days = 800 resin
Droprate is 2 to 3 → overall medium droprate is 2.5 boss mat per round
800 resin ÷ 40 resin = 20 rounds
20 rounds x 2.5 boss mat = 50 boss mat
Artifact drop from Boss run:
Total fodder value = 7,560 exp per round
7,560 exp x 20 rounds = 151,200 fodder exp
Enough fodder to raise → 1x lv.15/ almost lv.16 5☆ artifact
(not counting any x2 or x5 bonus that might occur in between)
Comparison value:
150k is nothing much compared to 500k from pure artifact domain farming, but if you plus 150k + 400k from free daily fodder, that equals to = 550k fodder exp, and still 800 more resin to spare.
Bosses also give 5☆ artifacts, so you're not going home without a chance to earn potential artifacts, just like when farming in any other domains.


*image source: link

☑ 6 x 10 Gems
The subsequent results after farming boss mats. Droprate of actual Gems is only 2 (timeline: here and here, 1 month apart). The rest, I converted for display.
5 days of resin: 800 resin = 20 rounds
Boss run:
Guaranteed droprate of each round = 2 sliver + 1 fragment
20 rounds = ( 2 sliver x 20 ) + ( 1 fragment x 20) = 40 sliver + 20 fragment
*droprate source: link
Daily commission:
1 day = 1 sliver
5 days = 5 sliver
350 days = 350 sliver
Weekly boss:
Weekly = 3.6 sliver + 2 fragment
Number of weekly bosses = 5
Total from weekly boss = ( 3.6 sliver x 5 ) + ( 2 fragment x 5 ) = 18 sliver + 10 fragment (*if do all)
*droprate source: link
Resin used = ( 30 x 3 ) + ( 60 x 2 ) = 90 + 120 = 210 resin
1 week = 160 resin x 7 days = 1,120 resin
5 days of boss run + weekly boss = 800 + 210 = 920 resin
Remaining unused = 200 resin
Total from boss run + weekly boss + 6 days commission = ( 40 sliver + 20 fragment ) + ( 18 sliver + 10 fragment ) + 6 sliver
= 64 sliver + 30 fragments
Convert to Gem = ( 64 sliver ÷ 27 ) + ( 30 fragments ÷ 9) = 2.3 + 3.3 = 5.6 rounded down to → 5 Gem every 6 days.
Conclusion:
I don't actively farm gems, but if you let them pile up, eventually you don't even have to go out of your way to farm these stones. You'll just have enough sliver to convert them.


☑ 10 x 9 Weapon Mats
5 days of resin: 800 resin = 20 rounds
Assuming only getting worse luck = 4 bronze + 4 onyx (per 40 resin)
20 rounds = ( 4 bronze x 20 ) + ( 4 onyx x 20 ) = 80 bronze + 80 onyx
*droprate source: link
Convert to Gold = ( 80 bronze ÷ 27 ) + ( 80 onyx ÷ 9 ) = 2.9 + 8.8 = 11.7 rounded down to → 11 Gold per 5 days worth of resin.
Total mats needed to max a 5☆ =

*number source: link
5 bronze + 14 onyx + 14 silver + 6 gold
Farming time = 2 times of 5 days value.
Total mats needed to max a 4☆ =

*number source: link
2 bronze + 9 onyx + 9 silver + 4 gold
Farming time = 1 time of 5 days value.


☑ Mob Drops
I don't actively gather them, as they do pile overtime just from defeating enemies from daily commissions. But if you'd like to gather specific mob drops, you can do mob farming via coop at discord. Doing it with 4 people will speed things up faster.
☑ EXP Books
My leyline number is still ±400. Most of these I got from events and BP. Characters I actively use are in lv.80. I only 90 them when I'm sure I'll still use them 5 years from now.
5 days of resin: 800 resin ÷ 40 resin = 20 rounds
Blue Leyline run:
40 resin Droprate = 8 hero's wit + 6 adventurer's exp
Total = ( 8 hero's wit x 20 ) + ( 6 adventurer's exp x 20 ) = 160 hero's wit + 120 adventurer's exp
*droprate source: link
Comparison value:
Using those 800 resin for exp books is always a benefit. Each character needs this many exp in total to max. More so whenever you wanna add a new unit to your team. 5 days worth of resin can get you ⅓ of the way. 415 hero's wit means you only need to save 13 days worth of resin. It's not so bad, but your real challenge will be talent books ⬇️.

*total exp source: link


☑ Talent Books
Compared to any other mats when upgrading a character, talent books always take the most/longest to finish.
5 days of resin: 800 resin ÷ 40 resin = 20 rounds
Domain run:
40 resin Droprate = 4 silver + 4 bronze
20 rounds = ( 4 silver x 20 ) + ( 4 bronze x 20 ) = 80 silver + 80 bronze
Convert to Gold = ( 80 silver ÷ 3) + ( 80 bronze ÷ 9 ) = 26.6 + 8.88 gold = 35.5 rounded down to → 35 Gold
*droprate source: link
If each character goes up to Lv.9 talent (DPS):
3 x [ (3 bronze) + (21 silver) + (22 gold) ] = 9 bronze + 63 silver + 66 gold
Farming time = about 3 times of 5 days value
If each character goes up to Lv.9 talent (support):
2 x [ (3 bronze) + (21 silver) + (22 gold) ] = 6 bronze + 42 silver + 44 gold
Farming time = about 2 times of 5 days value


*number source: link


☑ 40m Mora
I am down -10m every time I upgrade a character, and it does take a few months to get back to my original number, even with BP.
5 days of resin: 800 resin ÷ 40 resin = 20 rounds
*droprate source: link
Yellow Leyline run:
40 resin Droprate = 120,000 mora
20 rounds x 120,000 mora = 2,400,000 mora


Afterwords
I do get some decent artifact rolls from farming boss mats. I also run artifact domains once I'm all stocked up.
The roll luck is as good as can be expected. A.k.a. only 1 decent rolls once every blue moon. The rest are fodder.
(I've tried the 'spam-farm' method before, I'd know 🍋= v =🧂)
To those who would rather do the opposite (farm artifact domains, convert artifacts via strongbox after) here's a calculation post: link
I can also do a pure lemon and salt artifact farm, if there's enough request, just to see the numbers. I'll set aside 1 month for it. Or, if there's any data volunteer?

More guides:
[Beginner's Guide] Artifact Declutter
[Beginner's Guide] 📙 Efficient Artifact Levelling 🏆
[Inazuma Guide] Artifact Respawns 75k Exp hot 🔥


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